2018-02-18

Upstream Process Development Scientist
Job Opportunity at Spark Therapeutics, Inc

Posted on Feb 18

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4150579

The Upstream Process Development Scientist is involved in the development, scale-up, optimization, technology transfer, characterization and validation of recombinant adeno-associated viral vector (rAAV) production processes.   The Upstream Process Development Scientist executes experiments, develops production procedures and other relevant documentation, and works under supervision.
 
Job responsibilities are as follows:
  • Plans procedural and experimental approaches to meet Process Development objectives.
  • Cultures mammalian cells for viral production in shake flasks, spinner flasks, and/or bioreactors.
  • Performs experiments in the development, optimization and scale-up of production processes; contributes to the development of recovery processes.
  • Interprets experimental results; suggests changes or additional experiments to improve the robustness and/or reproducibility of the manufacturing process.
  • Actively participates in discussions regarding the troubleshooting of manufacturing processes and/or investigations; performs supporting studies as needed.
  • Participates in technology transfer from process development to manufacturing sites; assists in training manufacturing staff as needed.
  • Participates in process characterization, and process validation activities.
  • Establishes operating equipment specifications.
  • Prepares and reviews process development protocols, data analysis summaries, technical reports, process descriptions, and other relevant process documentation.
  • Maintains an accurate laboratory notebook.
  • Ensures work conforms to applicable quality and safety standards.
  • May participate in the development of patent applications.
  • May participate on project teams.
  • Other duties as assigned

RESPONSIBILITIES:
15%               
  • Plan/design experiments; prepare protocols for studies as needed.
50%               
  • Execute laboratory experiments.
25%               
  • Draft and/or review technical process development reports and any other relevant process documentation
10%               
  • Attend meetings, prepare presentations, participate in training sessions, perform administrative duties.

QUALIFICATIONS:
  • Expertise and hands-on experience in the development, scale-up, and technology transfer of cell culture production processes.
  • Working knowledge of state-of-the-art principles, technologies, and instrumentation.
  • Experience with production/manufacturing instrumentation is desired.
  • Demonstrated ability to evaluate, refine, and implement new processes.
  • Effective communication skills (verbal, written, interpersonal). Must be able to write protocols and technical reports.
  • Must be able to interact with cross-functional teams. 
  • Analytical and problem-solving skills. Ability to simplify complicated processes.
  • Ability to manage time effectively. Demonstrated planning and organizational skills.
  • Proficiency in MS Office.
  • Familiarity with statistical design/analysis software is a plus.

REQUIREMENTS:
  • Ph.D. in chemical engineering, chemistry, biochemistry, or molecular biology or related area and a minimum of 2-5 years of relevant scientific or technical experience in the life sciences industry; or equivalent.  Experience in the development and scale-up of cell culture production processes is essential.  Experience with viral vector production, and knowledge of recovery and purification process development is preferred.  

WHO WE ARE:
 
Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.





































SPRKProcessDevelopment

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