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Senior Research Scientist
Job Opportunity at
Spark Therapeutics, Inc
Posted on Feb 18
The Research Scientist is a key member of the Liver Discovery Research Group and participates in the development of Spark’s liver-targeted gene therapy products. She/he will actively participate in the development of novel targets, facilitating translation from in vitro through in vivo proof of concept.
He/she will be responsible for:
Collaborating with other Translational Research Scientists to develop pre-clinical programs from early discovery to the clinic.
Designing and conducting in vitro and in vivo experiments to optimize pre-clinical development of liver-directed candidates.
Initiating and overseeing joint programs with external collaborators.
Writing study reports, manuscripts and present results at appropriate scientific meetings.
The Senior Research Scientist position requires extensive experience with molecular biology, biochemistry and immunoassays including:
Design and construction of optimized gene expression cassettes to increase transgene expression derived from liver cells.
Experience with design, execution, and data analysis of experimental studies utilizing both cell-based and in vivo models.
Some experience or familiarity with liver-directed gene therapy and/or AAV vectors is preferred.
Work in the labs to perform experiments described above in the primary job duties
Design experiments, organize, discuss, and record experimental data.
Generate technical reports, prepare presentation slides, generate novel concepts.
Trainings, lab meetings and administration work
Experience in general and advanced lab techniques such as molecular cloning, plasmid design and construction, qPCR, ELISA, luciferase and enzymatic activity assays, SDS-PAGE/western blotting, etc.
Experience with studies in laboratory animals.
Strong analytical skills and problem-solving capabilities
Proven ability to work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
Excellent communication (oral and written) skills
Familiar with computer software commonly used in bio/pharma industries.
Works with colleagues as a team player.
Strong organizational skills.
Strong publication record is a plus.
Experience managing external collaborations is a plus.
Experience with AAV vectors is preferred.
Ph.D. in relevant scientific discipline required (e.g. cell and molecular biology, biochemistry, etc.)
Generally has at least 5 years of hands-on research experience with gene therapies targeting the liver
WHO WE ARE:
Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team
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