Senior Research Associate
Job Opportunity at Spark Therapeutics, Inc

Posted on Jun 4

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4156867

This position within the Translational department consists of two major roles. First, the successful candidate will be required to interact with contract research organizations (CROs) and external collaborators in order to coordinate the planning, design, and execution of the in-life portion of a variety of in vivo studies. Second, the successful candidate will support the research teams performaning assays on the bench. The main responsibilities of this position include but are not limited to the following:
  • Work cross-functionally across the translational department to coordinate the logistic and technical aspects of the different studies, including sample/reagent shipment and storage, ensuring all personnel involved in these studies is equipped with the adequeate time and material resources to process the samples according to project time lines.
  • Regular assay performance across the different pipeline programs (e.g. ELISA, NAb assay, etc).
  • Lead the implementation and management of an inventory system for biological reagents (plasmids, cells, vectors).
  • Provide guidance to new and existing employees that will allow them to achieve autonomous operation in the lab ensuring work is completed according to project time lines.
  • Support the lab manager in coordinating the work load.
  • Champion all safety aspects in the Translational Laboratories.

  • Plan, prepare and perform experiments on the bench in support of the translational Department goal. 
  • Oversee and/or provide operator training. Assist technical staff in the performance of laboratory experiments as needed.
  • Coordinate non-human promates studies and CRO interaction.
  • Support the lab manager in the short term planning of lab operations.
  • Implement and maintain Spark Translational inventory system.
  • Supplier & Vendor Management and negotiations.
  • Manage translational research samples and materials.

  • Strong organizational skills.
  • Excellent writing and verbal communication skills.

  • Bachelor’s degree required; Masters in a relevant field preferred.
  • Minimum of 5-8 years laboratory experience.
  • Broad understanding of the technical and equipment needs in a lab as well as extensive hands-on experience with standard molecular and cell biology techniques such as DNA cloning, qPCR, ELISA, flow cytometry, cell culture, etc.
  • Experience with writing NHP and rodent study protocols and CRO interaction required
  • Experience with gene therapy and AAV vectors is a plus.


Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.

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