Senior Lab Associate
Job Opportunity at Spark Therapeutics, Inc

Posted on Jan 9

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4149722

Support the lab manager in the day-to-day technical operation of the translational lab, inclusive of:  assay development, pharmacology & toxicology, and discovery research.
  • Maximize operating effectiveness of translational research programs:
    • Ensure optimal interactions across functions
    • Develop and implement processes that maximize productivity
    • Develop and improve assay protocols
    • Optimize resource utilization
    • Support the evolution of operating models to meet growth objectives
      • Provide input and feedback regarding organizational design, space planning and change management
  • Work cross-functionally across the translational department to coordinate the logistic and technical aspects of the different studies, including sample/reagent shipment and storage, ensuring all personnel involved in these studies is equipped with the adequeate time and material resources to process the samples according to project time lines.
  • Regular assay performance across the different pipeline programs (e.g. ELISA, NAb assay, etc).
  • Lead the implementation and management of an inventory system for biological reagents (plasmids, cells, vectors).
  • Provide guidance to new and existing employees that will allow them to achieve autonomous operation in the lab ensuring work is completed according to project time lines.
  • Support the lab manager in coordinating the work load.
  • Champion all safety aspects in the Translational Laboratories.

  • Plan, prepare and perform experiments on the bench in support of the translational Department goal. 
  • Oversee and/or provide operator training. Assist technical staff in the performance of laboratory experiments as needed.
  • Coordinate and align centralized lab support efforts across assay development, pharmacology, toxicology and discovery research.  
  • Support the lab manager in the short term planning of lab operations.
  • Implement and maintain Spark Translational inventory system.
  • Supplier & Vendor Management and negotiations.
  • Manage translational research samples and materials.

  • Strong organizational skills.
  • Excellent writing and verbal communication skills.

  • Bachelor’s degree required; Masters in a relevant field preferred.
  • Minimum of 5-8 years laboratory experience.
  • Broad understanding of the technical and equipment needs in a lab as well as extensive hands-on experience with standard molecular and cell biology techniques such as DNA cloning, qPCR, ELISA, flow cytometry, cell culture, etc.
  • Experience with AAV vectors is a plus.


Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.

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