2018-06-27

Pre-Clinical Manufacturing Specialist- Entry level
Job Opportunity at Spark Therapeutics, Inc

Posted on Jun 27

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4162622

Reporting into the Pre-clinical Manufacturing Lead, the primary responsibility of the Pre-Clinical Manufacturing Specialist is to manufacture GLP and R&D grade vectors. 
 
This position is a key participant in the day-to-day operation and planning of rAAV vector production related work, with primary responsibility to execute established protocols of manufacturing research and pre-clinical grade rAAV vectors.  The individual in the role will participate in (but not be limited to) manufacturing of rAAV vectors including cell culture, vector production and purification, and rAAV related assays. Additionally, the individual will contribute to the implementation of documentation in order to support research and GLP rAAV vector manufacturing.
 
This position requires good knowledge and experience with cell culture and good knowledge and skills related to purification of bio-products and related assays. Good written and verbal communication skills and ability to work effectively in a team environment are required. 

RESPONSIBILTIES:
65%      
  • Hands-on cGLP manufacture in assisting upstream virus production and downstream purification
25%      
  • Prepare manufacturing support materials such as media and buffers and equipment preparations
10%      
  • Review and revise SOPs and batch records for virus production and purification
  • maintain manufacturing and equipment records
  • Maintain laboratory safety procedures and compliance records
  • Participate in other projects upon request

QUALIFICATIONS:
  • Candidate must be adaptable and capable of working in various areas requiring intellectual and professional approaches.
  • Candidate should have the ability to work accurately, cooperatively with others and pay strict attention to detail.
  • Good written and verbal communication skills and ability to work effectively in a team environment are required.
  • Candidate should additionally have excellent organizational skills.

REQUIREMENTS:
  • Bachelor's degree in biology, biomedical, chemistry, or engineering required
  • 0-2 years of relevant work experience
  • Experience with cell culture or protein purification a plus
  • Must have good written and verbal communication skill
  • Must possess thorough knowledge of Microsoft Office Suite
  • Must understanding of basic cGLP regulations

WHO WE ARE:

Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.











































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