Ocular Research Scientist
Job Opportunity at Spark Therapeutics, Inc

Posted on Mar 10

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4149710

The Ocular Research Scientist is a member of the Ocular functional group within Translational Research.

He/she will be responsible for:
  • Design, execution and data analysis for ocular-directed research programs.
  • Write study reports, manuscripts and present results at appropriate scientific meetings.
  • Initiate and oversee joint programs with external collaborators.

  • Hands-on execution of in vitro and in vivo experiments on the bench.
  • Identify and validate new indication targets and evaluate gene expression cassettes to support both existing and new programs in the pipeline. This includes executing experiments on the bench, extensive literature review, championing product candidate development from proof of concept to IND submission, etc.
  • Prepare sample analysis reports and write parts of regulatory submissions to regulatory agencies.

  • Extensive hands-on experience in ocular gene therapy in animal models, such as intravitreal and subretinal injections, pupillometry, ERG, OCT, etc.
  • Strong molecular analysis skills, such as RNA and protein analysis and immunohistochemistry.
  • Strong organizational skills.
  • Excellent writing and verbal communication skills.

  • Ph.D. in relevant scientific discipline required (e.g. cell and molecular biology, biochemistry, etc.)
  • Minimum 3-5 years of hands-on research experience with gene therapies targeting the eye.
  • In-depth familiarity with target lead identification/optimization using a combination of molecular, cellular and in vitro/in vivo techniques for ocular gene therapy programs.
  • Experience with delivery techniques targeting the eye (subretinal and intravitreal injections).
  • Experience with studies in laboratory animals.
  • Experience with AAV vectors is required.
  • Molecular biology proficiency is required.
  • Strong publication record is a plus.

Transforming Patient’s Lives.
 Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.

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